Peter Molyneux, the founder of Lionhead Studios, is already hard at work on Fable 3. He's promised to include some really unique gameplay elements but when it came to confirming the use of Natal controls, no confirmation was given.
"Do you really think, knowing me, as maybe you do over the years, I wouldn't want to use something like Natal?" Molyneux said in an interview with Game Kings. "I mean, that's just mad, man."

"I am going to say it's going to use a controller, but I've never said it's not going to use Natal," he cautioned.

"And obviously what would probably happen if I started talking about this is you would see a little red dot appear moving on my forehead," Molyneux explained. "And then as I would start to speak the words then there would be a shotgun fire, and I would be assassinated. Quite clearly, it is that sensitive."
So there, in case you were wondering if Fable 3 will use Natal you now have your non-answer response. Enjoy the guessing game until more concrete information on Fable 3 trickles in in 2010.